For aesthetic practitioners, mastering perioral rejuvenation is essential. The area around the mouth is highly dynamic -smiling, talking, eating… humans we use the mouth a lot- and prone to volume loss, wrinkles, and structural change, so it’s normal that, with age, wrinkles and changes accumulate in the perioral area more than in the other parts of the body.

Dermal fillers offer an effective solution for restoring balance and youthfulness around the mouth.

In this guide, we’ll cover:

  • Key concerns that can be corrected with fillers around the mouth
  • Top and most used professional fillers for perioral treatments
  • Cost comparison of those products
  • Duration of the correction and post-treatment considerations
  • Information about treatments with fillers on other facial areas

Common Aesthetic Concerns Corrected with Perioral Fillers

The perioral region presents multiple challenges that can be addressed with strategic filler treatments.

The most common concerns around the mouth that can be corrected with fillers are:

  1. Marionette Lines – Vertical folds extending downward from the mouth corners, often contributing to a sagging appearance.
  2. Nasolabial Folds – Deep creases running from the nose to the mouth, requiring mid-to-deep dermal filler placement.
  3. Perioral Rhytides (also known as smoker’s lines) – Fine vertical wrinkles above the upper lip, best treated with low-G’ hyaluronic acid (HA) fillers.
  4. Downturned Mouth Corners – Loss of support at the oral commissure can be lifted with precise volumizing.
  5. Lip Border Definition – Restoring sharpness to the vermilion border enhances lip structure.
  6. Pre-Jowl Sulcus – Early jowling can be softened by reinforcing volume along the jawline.

Selecting the right filler, based on its rheological properties, is crucial for natural-looking, long-lasting results around the mouth.

Best Professional Fillers for the Perioral Area

At TopDermal, we supply premium dermal fillers specifically formulated for perioral treatments.

Below are the most trusted products among professionals (you can find them all in our online dermal filler catalog) that directly or indirectly designed for the around-the-mouth area.

Juvederm Ultra Smile (Lips)

Juvéderm Ultra Smile is specifically formulated to provide full, soft, natural looking lips, and is used to enhance lip volume, redefine lip shape and to correct vertical lip lines. Juvéderm Ultra Smile can also be used to correct lines around the mouth. Juvéderm Ultra Smile contains lidocaine to ensure a more comfortable injection.

  • Price: €153
  • Best for: full, soft, natural looking lips
  • Buy online

Teosyal Kiss

Teosyal Kiss is designed for the lip area. Its formula is specifically designed for lip augmentation, correction of the lip contour, smoothing away mouth wrinkles, lip rehydrating, and lip corner support. Like Juvéderm Ultra Smile, Teosyal Kiss PureSense contains 0,3% Lidocaine, which is a common local anesthetic used for reducing the pain of the injection and increasing the comfort of the patient.

  • Price: €190
  • Best for: Natural lip enhancement & fine lines
  • Buy online

Belotero Balance

Belotero Balance is a hyaluronic acid (HA) injectable filler that completely integrates into the skin tissue. While some fillers are designed to rebuild facial volume and structure, Belotero Balance specifically treats moderate-to-severe etched-in lines and wrinkles such as vertical lip lines above and around the lips.

  • Price: €92
  • Best for: Superficial wrinkles & fine lip lines
  • Buy online

Stylage Special Lips

Stylage Special Lips has been specifically designed to enhance the lips, creating subtle fullness and correcting lip contours. Use Stylage Special Lips for correction of a disproportionate upper or lower lip size, reducing perioral lines or smoker’s lines above the upper lip and restoring lip hydration.

  • Price: €78
  • Best for: Hydration & lip structure
  • Buy online

Juvederm Volift

Juvéderm Volift with lidocaine should be used for the treatment of deeper skin lines and wrinkles, and for facial contouring and restoring lost volume in the midface. Juvederm Volift also comes with lidocaine in the formula to ensure a more comfortable treatment.

  • Price: €263
  • Best for: Mid-to-deep folds & volumizing
  • Buy online

Belotero Volume (2 x 1ml)

Belotero Volume is specifically balanced to restore the facial volume in areas with extensive volume loss. It has the optimal modeling capacity and is intended for injection below the surface of the skin to increase volume, correction and fill moderate wrinkles, nasolabial folds, marionette lines, contours of the mouth and commissures.

  • Price: €205
  • Best for: Structural support & deeper folds
  • Buy online

Restylane Wrinkle Corrector

Restylane with lidocaine is used to add volume and fullness to the skin and to correct fine lines and wrinkles between the eyebrows, on the forehead and the bilateral lines between the nose and mouth (nasolabial folds). However, is common that some professionals use Restylane also for lip enhancementin some specific cases.

  • Price: €98
  • Best for: Fine lines & superficial wrinkles
  • Buy online

Juvederm Volbella

Juvederm Volbella with lidocaine is a facial filler specifically developed for the best results in the lips and bucal area of the patient, for gently restoring lip volume and defining lip appearance and contours. It is formulated to give a soft, natural before & after result, and can also be used to treat superficial facial lines and wrinkles around the chin. Juvederm Volbella also contains lidocaine, like some of the fillers mentioned above.

  • Price: €270
  • Best for: Subtle lip enhancement & perioral lines
  • Buy online

Juvederm Ultra 3

Juvéderm Ultra 3 is designed for a smooth, enhancing and long-lasting formulation. It is primarily used to fill moderate to deeper facial wrinkles that occur around the nose and the mouth: nasolabial folds and marionette lines. It can be also used to enhance lip contour and lip volume and for volumising of acne scars.

  • Price: €184
  • Best for: Moderate wrinkles & lip shaping
  • Buy online

Belotero Intense

Belotero Intense can be used to create a volumizing effect to nasolabial folds, marionette lines, lip contours, lip volume, oral commissures, and Cupid’s bow.

  • Price: €98
  • Best for: Stronger correction in dynamic areas
  • Buy online

Juvederm Ultra 4 (Volumising)

Juvéderm Ultra 4 has a high concentration of hyaluronic-acid specifically developed to treat and smooth deep skin face depressions and deeper folds and wrinkles. Is specifically intended for volumising and can correct deeper facial lines and wrinkles that are around the nose and mouth, including enhancing volume effects in the cheeks, chin and frown.

  • Price: €224
  • Best for: Deep folds & structural support
  • Buy online

Saypha Rich

Saypha Rich is hyaluronic acid-based, and is widely used for revitalizing the skin in mesotherapy treatments. Its formula consists of non-animal hyaluronic acid stabilized with glycerol.

  • Price: €36
  • Best for: Budget-friendly superficial corrections
  • Buy online

Cost Comparison of Top Perioral Fillers

For quick reference, here’s a breakdown of pricing for the best fillers around the mouth that we mentioned above:

Product Price Link
Juvederm Ultra Smile (Lips) €153 Buy online
Teosyal Kiss €190 Buy online
Belotero Balance €92 Buy online
Stylage Special Lips €78 Buy online
Juvederm Volift €263 Buy online
Belotero Volume (2 x 1ml) €205 Buy online
Restylane Wrinkle Corrector €98 Buy online
Juvederm Volbella €270 Buy online
Juvederm Ultra 3 €184 Buy online
Belotero Intense €98 Buy online
Juvederm Ultra 4 (Volumising) €224 Buy online
Saypha Rich €36 Buy online

Duration & Post-Treatment Considerations

The longevity of perioral fillers varies based on product composition. The duration you can expect is:

  • Hyaluronic Acid (HA) Fillers: Typically last 12–18 months, depending on the cross-linking density and injection technique.
  • Calcium Hydroxylapatite (CaHA) Fillers: May persist longer, though HA remains the gold standard for fine lines.

For a detailed breakdown of filler longevity by treatment area, read our in-depth guide about the topic: How Long Do Fillers Last?

Post-Treatment Potential Side Effects

Mouth fillers are a very common treatment and side effects are rare. Also, possible side effects can be minimized using the correct product, needle/cannula, and a correct injection depth and technique.

Some of the most common side effects are:

  • Mild swelling or bruising may occur but usually subsides within 24–48 hours.
  • Discomfort is minimal and transient.
  • Swelling can be minimized by using appropriate needle/cannula size and proper injection technique.

Beyond the Mouth: Expand The Filler Treatments You Offer In Your Clinic With Our In-Detail Guides

While perioral rejuvenation is a key focus, fillers offer versatile solutions for multiple facial areas.

We have written a few guides about how dermal fillers can be used depending on the injection area.

Check all these guides below:

In our blog you will find more expert insights on advanced aesthetic treatments, guides and comparison articles.

This Content Is For Professionals Only

Note that TopDermal.com supplies dermal fillers exclusively to licensed professionals.

If you are an end user, we strongly advise consulting a qualified practitioner: never self-administer fillers and do not buy anything online by yourself. Should be a medically certified professional who knows about fillers and human anatomy the one who decides what’s the best product, injection technique and number of sessions needed for a given patient.

If you are professional or clinic reading this: join us! At TopDermal we have extensive experience in the B2B dermal fillers sector.

We offer:

Stock up your clinic or practice on premium fillers with TopDermal.