In recent decades, soft tissue fillers have become increasingly popular as a non-surgical treatment option for facial rejuvenation. Calcium hydroxylapatite (CaHA) is a naturally occurring substance that has been approved by the FDA for use in a variety of dermal fillers. 

Although, calcium hydroxylapatite is biosynthetically produced, it is present naturally in the enamel and bone cells of humans. CaHA is a highly effective and safe treatment option for a wide range of aesthetic indications, including the correction of moderate-to-severe facial lines and folds, as well as the replenishment of lost volume.

Mechanism of action

Calcium hydroxylapatite is an injectable dermal filler that comes in the form of microspheres suspended in an aqueous carboxymethylcellulose gel carrier and is injected into the skin. After entering the tissues, the gel conductor fills the hollow beneath and the skin around it becomes elastic, causing the creases to rise. The gel is eventually removed by macrophages, leaving just the hydroxyapatite microspheres, which promote endogenous collagen formation by the body, and collagen, in turn, builds a new skin matrix. After a while, calcium hydroxyapatite is entirely cleared from the body, and the skin’s qualities continue to improve.

Differences between Calcium Hydroxylapatite based fillers and other fillers 

CaHA fillers have a thicker consistency than other injectables and have a substantially longer duration of action than other fillers. Because this chemical is very biocompatible with human tissue, there is a much lower risk of allergic responses to the injections, and a very low risk of complications. Moreover, CaHA is twice as efficient as hyaluronic acid, and it combines high elasticity and viscosity with the capacity to stimulate long-term collagen synthesis, making it a perfect agent for a comprehensive face treatment.

CaHA’s spectrum of applications has expanded in tandem with advancements in the area of aesthetic medicine, from a surface-oriented two-dimensional approach concentrating on the treatment of facial wrinkles and folds to a three-dimensional strategy that targets both soft and hard tissue volume loss in the face and hands. 

Calcium hydroxyapatite-based filler is used to solve the following problems:

  • To replace lost quantities in the cheeks and chin;
  • To fill the nasolabial folds;
  • To eliminate marionette lines;
  • To restore clear lines and eruptions to the skin;
  • To restore skin’s firmness and elasticity;
  • To correct face oval correction;
  • To smooth and replenish the dermis on the hands;
  • To lift the tip of the nose.

Important notes:

One of the main advantages of calcium hydroxylapatite is that the results are immediate. Calcium hydroxylapatite is a good choice when the treated region requires significant volume restoration since it takes up more space than other dermal fillers.

The skin condition improves when a new tissue frame is generated with collagen fibers and microspheres and the dermis becomes more elastic. It’s expected to last between a year and 18 months. Although CaHA is a semi-permanent wrinkle filler, further injections may be required to maintain the effect.


Injection of CaHA into the oral mucosa and the lips is an unapproved indication and may result in nodule formation. This occurs soon after injection and is a result of accumulated particles and not a granulomatous reaction. No osteogenesis has been reported in extensive literature describing the use of CaHA in a variety of soft tissue applications.


Long-term clinical experience have demonstrated that calcium hydroxylapatite is a very effective agent for many areas of facial soft tissue augmentation and is associated with a high and well-established safety profile.

We currently provide a wide range of aesthetic products including those with calcium hydroxylapatite, such as:



The most common brand of CaHA filler is Radiesse, which is an injectable dermal filler comprised of calcium hydroxyapatite (CaHA) globules as well as additional ingredients such as glycerin and sodium carboxymethylcellulose. Radiesse’s components are non-toxic, hypoallergenic, and compatible with the body’s regular tissues.

Radiesse possesses one of the highest viscosities and elasticity qualities when compared to other dermal fillers, resulting in better lifting capacity while preserving cohesiveness. This also allows it to remain in place rather than migrating into the surrounding tissue where it is injected.

Radiesse provides both immediate replacement volume and long-lasting skin’s natural collagen biostimulation as a primary mechanism of action. Radiesse injections are commonly used in regions of the face, particularly around the nose and lips, to treat moderate to severe wrinkles. It is used to fill in laugh lines and restore the skin’s young look. Radiesse may be used to fill in the back of the hands and deep scars in some cases. Furthermore, Radiesse was assessed as superior than collagen in the treatment of a majority of the folds and required half the quantity of material as the collagen-treated folds.

Neauvia StimulateNeauvia Stimulate 

Neauvia Stimulate was designed for filling of deep skin depression, including deep wrinkles and nasolabial folds, as well as biostimulation and revitalization. It is the only product among Neauvia’s second-generation fillers that has a specific combination of pure hyaluronic acid cross-linked with PEG (polyethylene glycol) and micro molecules of calcium hydroxyapatite at low concentrations (1%). In addition to hyaluronic acid, the product contains the amino acids Glycine and L-Proline, which are key components of collagen.

Calcium hydroxyapatite used in Neauvia Stimulate has small particle size (8-12 microns) and is well spread in the cluster of the hydrogel. What makes it a unique product is the combination of high filling capacity due to hydrogel’s excellent rheological properties with a documented stimulating action on the neocollagenesis process.

Neauvia Hydro DeluxeNeauvia Hydro Deluxe

Neauvia Hydro Deluxe is a dermal filler that combines deep hydration, renewal, and biostimulation. This filler is used to increase skin density, regeneration, the repair of superficial wrinkles, and the rejuvenation of the hands.

Neauvia Hydro Deluxe’s potent activity is based on highly concentrated hyaluronic acid derived from Bacillus subtilis, and primarily utilized for hydration.  It also contains calcium and phosphorus components that stimulate the body’s natural collagen and elastin synthesis, resulting in immediate rejuvenation.