Last month we discussed the differences between Sculptra and Radiesse, since for some practitioners it might get a little confusing. Both of these fillers are classified as collagen biostimulators, that is they work to promote the growth of collagen and forming other skin proteins far after being injected. We even took a quick look at the very unique technique called MESO RADIESSE.

Today we decided to focus on Radiesse and explore the protocol for MESO RADIESSE in more details. Firstly, I want to explain here the skin aging process. This will help to understand what is Radiesse and how it works.


Skin aging is mainly related to atrophic changes in dermis and hypodermis. Destructive changes take place in fibroblasts. Lipofuscin and fat, which are underoxidized products of metabolism, begin to accumulate. Besides this, destructive and degenerative changes occur in macrophagocytes, where breakdown products of hemoglobin happens.

The collagen fibers themselves get atrophic and become less dense. Elastic fibers become coarse and become subject to partial fragmentation. They begin to concentrate in some areas, especially, under epidermis (SENILE ELASTOSIS).

In this case hypodermis plays the main role, as it participates in constitution of granulation tissue which is an important morpho-functional element of regeneration process. It contains a storage pool of poorly differentiated young and mature fibroblasts and fibro-clusterscontains collagen, elastic and reticular fibres.


Radiesse is an injectable filler, latex-free, non pyrogenic biocompatible material with over 20 years of use in medicine. It combines a gel with tiny calcium microspheres called CALCIUM HYDROXILAPATITE, which is structurally similar to what is found in our bones and teeth.

Radiesse activates fibroblasts to stimulate the collagen production, however, Radiesse is non-inflammatory (!!!) Instead the calcium particles become embedded in the the skin, it acts as a scaffold that promotes the growth of new surrounding tissues.

Radiesse: all about the product

The product is FDA approved for aesthetic facial augmentation, long-lasting correction of moderate to sever facial fat loss, which can also be caused by human immunodeficiency virus infection.

Diverse facial regions can be treated in order to improve or enhance some features:

  • Glabella lines,
  • Subdermal support of the brows
  • Malar and buccaneers fat pads
  • Nasolabial folds
  • Perioral region (NOTE: Radiesse should be specially diluted),
  • Marionette lines
  • Oral comissires
  • Chin
  • Saucerized acne scars

Radiesse gives the perfect tightening, lifting and shaping of the facial contours in the cheeks and jawline. It can be used for filling the temples as well (NOTE: Radiesse should be specially diluted).

The product can be used according to some medical indication, such as:

  • Nipple projection for nipple Areopagus reconstruction
  • Urinalysis incontinence
  • Vocal cord augmentation, etc.

The average lasting result is from 12 to 18 months. Radiesse can be considered an effective soft-tissue filler for overall longevity, biocompatibility, and low rate of side effects.

My absolute favorite in the skin anti-aging treatment is the unique skin reinforcement with Radiesse called MESO RADIESSE, which was developed by renowned professor and aesthetic practitioner Yana Yutskovskaya.


It is a special meso-technique to prevent and treat skin laxity, poor skin turgor and elasticity, pigmentation, post-acne scarring and just for glowing, young texture of skin.

Meso Radiesse technique before and after

The essence of this genius method lies within subdermal injection of the product not in the form of a gel in its pure concentration, but in a form of a solution dissolved in 0,9% saline solution (depending of volume and treating area) or with blood plasma (PRP) (powerfully rejuvenates and regenerates the skin tissues). The product has to be injected between dermis and hypodermics with a 28-29G needle or/and 25-22G x 50/70 mm cannula.

The aim of the method is to stimulate fibroblasts synthetic activity. You can use it in full face, tear troughs inclusive, neck, décolletage and hands rejuvenation.

Step1: After disinfection of the skin surface. Application of marking on the lower third part of the face, neck and decollete area. Marking is done along skin tension lines (Langer’s lines).

Step 2: Preparation of Radiesse product for meso-therapy injection technique. The ratio of the product and saline can be 1:1 – 1:2 (gel), 1:3 – 1:4 (gel/sol), 1:6 – 1:8 (sol). In the given case it is important to consider thixotropic character of the product – its capacity to restore its structure spontaneously after mechanical destruction (in our case after introduction of a needle). Gel is a dispersive system with liquid dispersive environment, where dispersed phase particles form a steric structural grid. Gel has a thixotropic nature. Sol is a suspensoid of hard matter particles in liquid. Sol differs from gel as it stays liquid and doesn’t solidify, therefore, doesn’t have thixotropic capacity.

Before filling each syringe for injection, it is necessary to stir the product thoroughly, because its particles deposit on syringe walls.

Step 3: In linear retrograde technique we primarily prepare the lower third part of the face, submental area, neck and, afterwards, decollete area.

Step 4: In order to ensure a better redistribution of the product after the procedure a vigorous massage with application of Traumeel ointment is carried out. Contouring can be observed after the procedure, but no “whitishness” is admissible.

We hope you found this post useful. If you are interested in a master-class for Meso Radiesse technique or any other topic, please contact Top Dermal team, and we’ll arrange a private training for you and/or your medical team.

Contributed by Dr. Irina Geliev